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To some extent, the Brexit vote removed an uncertainty, but the ramifications will continue to be processed as the U.K. lays out plans to exit the EU. There are also signs that anti-EU sentiment may be on the rise. Next among the sources of angst: one of the most polarizing U.S. presidential elections in modern memory. We also face persistent instability in the Middle East and questions around Russia and China’s assertiveness abroad while grappling with economic troubles at home.